Take 50 to route 4 north (east of STL) thru Lebanon, Take 17 miles of 70 and 270 to Rt 3 north. At mid-town Alton take Rt 100 west.
There are lots of Antique shops and the like here. Bicycle path on the river edge.
Take the Brussels Ferry (free) thru Golden Eagel Il, to the Golden Eagle ferry (cost $5.00),
this area is good for fresh peaches when in season.
Unfortunately it is GRAVEL for about a mile south of the ferry to the next blacktop. Rt B and Rt C to Mid-Rivers Mall area.
Then I-70 west to Warrenton and Rt 47 south.
(Might be good Highway Z south from Wentzville to New Melle then Rt D and RT T to Rt 47 thru Washington MO and then down to 50.)
(Haven't driven it but probably good.)
Alton cable-stayed bridge. US-67 just east of the casino.