
Originally Posted by
godzilla
US50 through Indiana is OK, but you should stick to the Ohio River for a more scenic and 'twisty' ride. US50 goes through Cincy, OH along the River. When you get to IN, follow the Scenic Road signs for a better ride. You'll go through Madison on your way through.
If it were me, I would use the Ohio River as a landmark from PA all the way through Ill. It's something that I've wanted to do. You could drop into Northern KY, too. There's lots of nice roads in S. IN and N. KY.