My folks live in Ft. Lauderdale area and I take Krome Ave through Homestead south and than ride Card Sound Road. A pit stop at Alabama Jack's is cool and the road is less traveled. The 18 Mile Stretch is under construction (this road is the one going straight south from Florida City)
Everglades Tours are good at Billy Swamp Safari on the buggies, the best air boat trips are the small boats on US 41 or in Everglades City. Don't get on a air boat with the capacity of a greyhound bus
If you have more questions lemme know..